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Cellular prion protein inhibits proapoptotic Bax conformational change in human neurons and in breast carcinoma MCF-7 cells

โœ Scribed by Roucou, X; Giannopoulos, P N; Zhang, Y; Jodoin, J; Goodyer, C G; LeBlanc, A

Book ID
110016940
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
631 KB
Volume
12
Category
Article
ISSN
1350-9047

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Ifosfamide metabolite chloroacetaldehyde
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โœ Burhan Knouzy; Laurence Dubourg; Gabriel Baverel; Christian Michoudet ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 299 KB

## Abstract Chloroacetaldehyde (CAA), a product of hepatic metabolism of the widely used anticancer drug ifosfamide (IFO), has been reported to decrease cancer cell proliferation. The basis of this effect is not completely known but has been attributed to a drop of cellular ATP content. Given the i