Principles of tissue engineering applied to programmable osteogenesis

✍ Scribed by Brekke, John H. ;Toth, Jeffrey M.

• Book ID: 102656379
• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 642 KB
• Volume: 43
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/(sici)1097-4636(199824)43:4<380::aid-jbm6>3.0.co;2-d

✦ Synopsis

This article presents a strategy for design, engineering, and fabrication of a bioresorbable, manufactured bone graft substitute (BGS) device. The approach is based on established precepts of osteogenesis, molecular biology of hyaluronic acid and osteoinductive proteins, and theoretical preformance criteria for such a device collated from the literature of 1991 to 1996. Application of this design and engineering strategy results in a composite device consisting of a D ,D-L,L-polylactic acid macrostructure optimized to the architecture of cancellous bone, a microstructure composed of a filamentous velour of hyaluronan and a recombinant human bone morphogenetic protein 2 (rhBMP-2). The performance of this construct was tested in vivo in the dog, intertransverse process, spinal fusion model and in a critical sized defect of the rabbit radius. Data from these studies are used to illustrate principle points of the design and engineering concept.