Principles of tissue engineering applied to programmable osteogenesis

✍ Scribed by Brekke, John H. ;Toth, Jeffrey M.

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 15 KB
• Volume: 48
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/(sici)1097-4636(1999)48:1<95::aid-jbm17>3.0.co;2-#

✦ Synopsis

It has been brought to the attention of the Publisher that the word intramembranous was misspelled in a paragraph. Also the Acknowledgements were omitted. We apologize for any inconvenience these errors may have caused.

Two factors inherent in the OPLA/HY/BMP device may work to inhibit cells committed to the chondroblast phenotype: early vascularization (leading to increased pO 2 levels) and the capacity for BMPs to induce direct, intramembranous bone formation. 86 -88 Chondrogenesis requires an avascular environment with low oxygen tension. 86 OPLA/HY constructs may be vascularized soon after implantation secondary to angiogenic effects of hyaluronan oligosaccharides. [45][46][47][48][49] Extracted bovine BMP, delivered via bovine type I collagen matrix, has been shown to induce bone via direct intramembranous ossification; foregoing cartilage precursor tissue required in endochondral ossification. 87 Cells geneti-cally committed to the chondroblast phenotype may find the OPLA/HY/BMP device an inhospitable environment.