✦ LIBER ✦

Primary structure and biological activity of hemoglobin-related hypothalamic peptides

✍ Scribed by A. A. Galoyan

Publisher: Wiley (John Wiley & Sons)
Year: 1997
Tongue: English
Weight: 33 KB
Volume: 43
Category: Article
ISSN: 0006-3525
DOI: 10.1002/(sici)1097-0282(1997)43:2<135::aid-bip6>3.0.co;2-w

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✦ Synopsis

Five individual fractions from bovine hypothalamic extract, displaying coronary constrictory activity, were isolated and sequenced. All of them belong to the hemorphin group of hemoglobin-derived peptides. These peptides bind calmodulin and activate calmodulindependent enzymes. The relationship of isolated peptides with other members of the hemorphin group is discussed. Several new fragments of hemoglobin a-and b-chains with yet unidentified activity were obtained from the same source. Their amino acid sequences have considerable overlap with the known sequences of hemoglobin fragments isolated from other tissues.

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