Primary screening approach for anti-inflammatory agents utilizing an in vivo and a new in vitro Method

Development and validation of an RP-HPLC

Development and validation of an RP-HPLC-UV method for the determination of BOL-303225-A, a new coumarin-based anti-inflammatory drug, in rat plasma

✍ Adriana Maltese; Francesco Maugeri; Keith W. Ward; Claudio Bucolo 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 181 KB 👁 3 views

## Abstract A simple and rapid high‐performance liquid chromatographic method was developed and validated for the analysis in rat plasma of BOL‐303225‐A, a new coumarin‐based anti‐inflammatory drug. Liquid–liquid extraction was used for sample preparation. Chromatographic separation was achieved on