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Primary lymphoma of the ampulla of vater

✍ Scribed by Joya Pawade; Soon C. Lee; David W. Ellis; Ivo D. A. Vellar; Jurgen Rode

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 447 KB
Volume: 73
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(19940415)73:8<2083::aid-cncr2820730812>3.0.co;2-b

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✦ Synopsis

A 57-year-old woman was investigated for obstructive jaundice with endoscopic retrograde cholangiopancreaticography that showed a tumor at the ampulla of Vater. A Whipple's procedure was performed. A protuberant tumor was present at the ampulla of Vater in the background of multiple mucosal polyps in the duodenum. Light microscopy revealed a diffuse non-Hodgkin's lymphoma with centrocytelike cells forming lymphoepithelial lesions and infiltrating the sphincter of Oddi. The duodenal polyps were hyperplastic lymphoid follicles with reactive germinal centers. Immunohistochemical staining characterized the tumor as a B-cell neoplasm with IgA heavy-chain and lambda light-chain restrictions. Complete remission of the disease occurred after surgery. The clinical, histologic, and immunohistochemical features of this lymphoma are suggestive of histogenetic derivation from mucosal-associated tissue. Cancer 1994; 73:2083-6.

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