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Carcinoma of the ampulla of Vater: Is radical lymphadenectomy beneficial to patients with nodal disease?

✍ Scribed by Shirai, Yoshio; Tsukada, Kazuhiro; Ohtani, Tetsuya; Hatakeyama, Katsuyoshi


Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
386 KB
Volume
61
Category
Article
ISSN
0022-4790

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✦ Synopsis


This study was undertaken to evaluate the effectiveness of radical lymphadenectomy in ampullary cancer with nodal disease. Thirty-five patients underwent the Whipple procedure with radical lymphadenectomy. The location and number of positive nodes was characterized. Eighteen patients (51%) had positive nodes. Patients without nodal disease (pNO group) had an actuarial 5-year survival rate of 81%. Seven patients with metastasis confined to the pancreaticoduodenal nodes had a 5-year survival rate of 67%, which was comparable to the pNO group (N.S.) and better than the 27% 5-year survival rate in patients with positive superior mesenteric nodes (P < 0.05). Eleven patients with one to three positive nodes had a 5-year survival rate of 71%, which was also comparable to the pNO group (N.S.) and better than the 0% 5-year survival rate in patients with four or more positive nodes ( P < 0.01). Radical lymphadenectomy is effective against a limited degree of nodal disease.


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