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Primary local anesthetic testing and acute toxicity of N,N′-disubstituted 2,3-diamino-2′,6′-propionoxylidides

✍ Scribed by H. Jack Adams; George H. Kronberg; Bertil H. Takman

Publisher
John Wiley and Sons
Year
1973
Tongue
English
Weight
290 KB
Volume
62
Category
Article
ISSN
0022-3549

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Local anesthetic activity and acute toxi
Local anesthetic activity and acute toxicity of (±) −2-(N-ethylpropylamino) −2′,6′-butyroxylidide, a new long-acting agent
✍ H. Jack Adams; George H. Kronberg; Bertil H. Takman 📂 Article 📅 1972 🏛 John Wiley and Sons 🌐 English ⚖ 286 KB

This paper is concerned with the local anesthetic activity and acute toxicity of (+~)-2-(N-ethylpropylamino)-2',6'-butyroxylidide (I). Testing in rat sciatic nerve blocks and guinea pig intradermal wheals showed that the compound has rapid onset, excellent frequency, and long durations of block. The