This placebo-controlled, randomized, multicenter trial compared the effects of MTX plus UDCA to UDCA alone on the course of primary biliary cirrhosis (PBC). Two hundred and sixty five AMA positive patients without ascites, variceal bleeding, or encephalopathy; a serum bilirubin less than 3 mg/dL; se
Primary biliary cirrhosis in elderly. Long-term treatment with ursodeoxycholic acid (UDCA)
β Scribed by R. Giner; O. Gonzalez; JJ Terradez; JV Ballester; M. Bixquert; R. Gil; J. Alegre; V. Cervera; J. Alonso
- Book ID
- 118881593
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 162 KB
- Volume
- 108
- Category
- Article
- ISSN
- 0016-5085
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π SIMILAR VOLUMES
Primary biliary cirrhosis (PBC) is a progressive cholestatic liver disease frequently leading to development of cirrhosis and its complications. Ursodeoxycholic acid (UDCA) is a beneficial medical therapy for patients with PBC. Improvement in some histological features, but not in histological stage
Biochemical response to ursodeoxycholic acid (UDCA) in patients with primary biliary cirrhosis (PBC) is variable. It has been recently proposed that an alkaline phosphatase (ALP) decline of more than 40% in baseline value or a normal level after 1 year of UDCA treatment (Barcelona criteria) could se