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Long term ursodeoxycholic acid (URSO) treatment improves glutathione status in primary biliary cirrhosis (PBC)

✍ Scribed by Philip Pemberton; Ali Aboutwerat; Alexander Smith; Sanjiv Jain; Ian Laing; Edward Mather; Thomas Warnes


Book ID
118565478
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
229 KB
Volume
36
Category
Article
ISSN
0168-8278

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Primary biliary cirrhosis (PBC) is a progressive cholestatic liver disease frequently leading to development of cirrhosis and its complications. Ursodeoxycholic acid (UDCA) is a beneficial medical therapy for patients with PBC. Improvement in some histological features, but not in histological stage

Biochemical response to ursodeoxycholic
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Biochemical response to ursodeoxycholic acid (UDCA) in patients with primary biliary cirrhosis (PBC) is variable. It has been recently proposed that an alkaline phosphatase (ALP) decline of more than 40% in baseline value or a normal level after 1 year of UDCA treatment (Barcelona criteria) could se

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We read with interest the article by Corpechot et al. in a recent issue of HEPATOLOGY. 1 Corpechot et al. identify the absence of a biochemical response to ursodeoxycholic acid (UDCA) as an important predictive factor for death or liver transplantation in patients with primary biliary cirrhosis (PBC

Long-term survival and impact of ursodeo
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The recurrence of primary biliary cirrhosis (PBC) in the hepatic allograft may impact patient and graft survival with long-term follow-up. The efficacy of ursodeoxycholic acid (UDCA) for treatment of recurrent PBC after liver transplantation (LT) remains less well known. The aims of this study were