Primary biliary cirrhosis and mitochondrial autoantigens—insights from molecular biology
✍ Scribed by M. Eric Gershwin; Ross L. Coppel; Ian R. Mackay
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 686 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
✦ Synopsis
Inner vs. outer mitochondria1 membranes.
Reacts equally well with mitochondrial preparation from a variety of organs.
📜 SIMILAR VOLUMES
We have previously identified four of the M2 antigens in primary biliary cirrhosis as the E2 components (dihydrolipoamide acyltransferases) of pyruvate dehydrogenase complex, branched-chain 2-0x0 acid dehydrogenase complex and 2-oxoglutarate dehydrogenase complex and the protein X component of pyruv
The E2 component of mitochondrial pyruvate dehydrogenase complex (PDC-E2) is the immunodominant autoantigen of primary biliary cirrhosis. Whereas lipoylation of PDC-E2 is essential for enzymatic activity and predominates under normal conditions, other biochemical systems exist that also target the l
Previous studies in which quantitative immunofluorescenm was used have shown that certain biliary epithelial cells in liver with primary biliary cirrhosis show i n d levels of pyruvate dehydrogenase dihyddipoamide acetyltransferase compared with controls. "his study was designed to determine whether