A screen of over 500 diversely functionalized additives in osmium-catalyzed dihydroxylation has uncovered that electron-deficient olefins are converted into the corresponding diols much more efficiently when the pH of the reaction medium is maintained on the acidic side. Further studies have identif
✦ LIBER ✦
Prilezhaev Dihydroxylation of Olefins in a Continuous Flow Process
✍ Scribed by Bas A. M. W. van den Broek; René Becker; Florian Kössl; Mariëlle M. E. Delville; Pieter J. Nieuwland; Kaspar Koch; Prof. Dr. Floris P. J. T. Rutjes
- Book ID
- 112071554
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2011
- Tongue
- English
- Weight
- 392 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1864-5631
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The highest enantioselectivities yet obtained in catalytic asymmetric dihydroxylations are realized using potassium hexacyanoferrate(II1) [potassium ferricyanide, K3Fe(CN)6] as the reoxidant. The use of potassium ferricyanide as the stoichiometric oxidant for osmium-catalyzed dihydroxylation of olef