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Prevention of progressive joint destruction in adjuvant induced arthritis in rats by a novel matrix metalloproteinase inhibitor, FR217840

โœ Scribed by Takeshi Ishikawa; Fusako Nishigaki; Susumu Miyata; Yoshitaka Hirayama; Kyoko Minoura; Junko Imanishi; Masahiro Neya; Tsuyoshi Mizutani; Yoshimasa Imamura; Yoshitaka Ohkubo; Seitaro Mutoh


Book ID
113585224
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
383 KB
Volume
508
Category
Article
ISSN
0014-2999

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Prevention of the onset and progression
โœ Masataka Nishikawa; Akira Myoui; Tetsuya Tomita; Koichiro Takahi; Akihide Nampei ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 488 KB ๐Ÿ‘ 2 views

## Abstract ## Objective FR167653 is a potent inhibitor of p38 mitogenโ€activated protein kinase (MAPK) and inhibits tumor necrosis factor ฮฑ (TNFฮฑ) and interleukinโ€1ฮฒ (ILโ€1ฮฒ) production in inflammatory cells. In this study we investigated the effect of FR167653 on collagenโ€induced arthritis (CIA).