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Prevention of progressive joint destruction in collagen-induced arthritis in rats by a novel matrix metalloproteinase inhibitor, FR255031

✍ Scribed by Takeshi Ishikawa; Fusako Nishigaki; Susumu Miyata; Yoshitaka Hirayama; Kyoko Minoura; Junko Imanishi; Masahiro Neya; Tsuyoshi Mizutani; Yoshimasa Imamura; Yoichi Naritomi; Hidetsugu Murai; Yoshitaka Ohkubo; Akira Kagayama; Seitaro Mutoh

Book ID
110008570
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
426 KB
Volume
144
Category
Article
ISSN
0007-1188

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Prevention of the onset and progression
Prevention of the onset and progression of collagen-induced arthritis in rats by the potent p38 mitogen-activated protein kinase inhibitor FR167653
✍ Masataka Nishikawa; Akira Myoui; Tetsuya Tomita; Koichiro Takahi; Akihide Nampei 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 488 KB 👁 2 views

## Abstract ## Objective FR167653 is a potent inhibitor of p38 mitogen‐activated protein kinase (MAPK) and inhibits tumor necrosis factor α (TNFα) and interleukin‐1β (IL‐1β) production in inflammatory cells. In this study we investigated the effect of FR167653 on collagen‐induced arthritis (CIA).