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Prevention of Naphthalene-Induced Cataract and Hepatic Glutathione Loss by theL-Cysteine Prodrugs, MTCA and PTCA

โœ Scribed by WILLIAM B. RATHBUN; HERBERT T. NAGASAWA; CHRISTINA E. KILLEN


Book ID
115604945
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
332 KB
Volume
62
Category
Article
ISSN
0014-4835

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## Abstract Naphthalene is metabolized in the lung and liver to reactive intermediates by cytochrome P450 enzymes. These reactive species deplete glutathione, covalently bind to proteins, and cause necrosis in Clara cells of the lung. The importance of glutathione loss in naphthalene toxicity was i