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Maintenance of hepatic glutathione homeostasis and prevention of acetaminophen-induced cataract in mice by L-cysteine prodrugs

✍ Scribed by William B. Rathbun; Christina E. Killen; Ann M. Holleschau; Herbert T. Nagasawa

Book ID: 115784608
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 641 KB
Volume: 51
Category: Article
ISSN: 0006-2952
DOI: 10.1016/0006-2952(96)00144-x

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## Abstract A series of double‐prodrugs of L‐cysteine, designed to release L‐cysteine in vivo and stimulate the biosynthesis of glutathione (GSH), were synthesized. To evaluate the hepatoprotective effectiveness of these double‐prodrugs, male Swiss‐Webster mice were administered acetaminophen (ACP)