## Abstract Commercial cow milk contains considerable amounts of estrogens. Our study assessed the effect of commercial low‐fat milk on the development of 7,12‐dimethylbenz(a)anthracene (DMBA)‐induced mammary tumors in rats. Eighty 6‐week‐old female Sprague‐Dawley rats received a single oral dose o
✦ LIBER ✦
Prevention of development of dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in the rat by the new nonsteroidal antiestrogen EM-800 (SCH57050)
✍ Scribed by Shouqi Luo; Claude Labrie; Alain Bélanger; Bernard Candas; Fernand Labrie
- Book ID
- 110230536
- Publisher
- Springer US
- Year
- 1998
- Tongue
- English
- Weight
- 801 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0167-6806
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The novel anti-estrogen EM-800 and medroxyprogesterone acetate (MPA) inhibit estrone (E 1 )-stimulated growth of dimethylbenz[a]anthracene (DMBA)-induced mammary tumors in a rat model. After 65 days, ovariectomy (OVX) decreased total tumor area to 9.6 ؎ 3.9% of initial size, while E 1 (1.0 µg, s.c.,