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Prevention of cartilage destruction with intraarticular osteoclastogenesis inhibitory factor/osteoprotegerin in a murine model of osteoarthritis

✍ Scribed by Sadanori Shimizu; Yoshinori Asou; Soichiro Itoh; Ung-Il Chung; Hiroshi Kawaguchi; Kenichi Shinomiya; Takeshi Muneta

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 308 KB
Volume: 56
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.22941

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## Abstract ## Objective Previous studies have demonstrated that neutralization of macrophage migration inhibitory factor (MIF) by anti‐MIF antibodies decreases joint inflammation and destruction in a type II collagen–induced arthritis model in mice. The aim of this study was to develop and descri