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Cilostazol protects rat chondrocytes against nitric oxide–induced apoptosis in vitro and prevents cartilage destruction in a rat model of osteoarthritis

✍ Scribed by Sung Won Lee; Yeon Suk Song; Sang Hwa Shin; Kyung Taek Kim; Young Chul Park; Bong Soo Park; Il Yun; Kunhong Kim; Sang Yeob Lee; Won Tae Chung; Hye Jeong Lee; Young Hyun Yoo

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
872 KB
Volume
58
Category
Article
ISSN
0004-3591

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## Abstract We investigated whether __N__‐acetylcysteine (NAC), a precursor of glutathione, could protect rabbit articular chondrocytes against nitric oxide (NO)‐induced apoptosis and could prevent cartilage destruction in an experimental model of osteoarthritis (OA) in rats. Isolated chondrocytes