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Prevalidation study of the BALB/c 3T3 cell transformation assay for assessment of carcinogenic potential of chemicals

✍ Scribed by Noriho Tanaka; Susanne Bohnenberger; Thorsten Kunkelmann; Barbara Munaro; Jessica Ponti; Albrecht Poth; Enrico Sabbioni; Ayako Sakai; Susan Salovaara; Kiyoshi Sasaki; B. Claire Thomas; Makoto Umeda

Book ID
116760029
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
701 KB
Volume
744
Category
Article
ISSN
1383-5718

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## Abstract A31–714, a subclone isolated from clone A31 of the BALB/3T3 line showed a high degree of contact inhibition and an extremely low incidence of spontaneous transformation. Treatment of this subclone with 4‐nitroquinoline‐1‐oxide, 3‐methylcholanthrene, benzo(a)pyrene or N‐methyl‐N'‐nitro‐N