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Prevalent role of Akt and ERK activation in cardioprotective effect of Ca2+channel- and beta-adrenergic receptor blockers

✍ Scribed by Krisztina Kovacs; Katalin Hanto; Zita Bognar; Antal Tapodi; Eszter Bognar; Gyongyi N. Kiss; Aliz Szabo; Gabor Rappai; Tamas Kiss; Balazs Sumegi; Ferenc Gallyas

Publisher
Springer
Year
2008
Tongue
English
Weight
528 KB
Volume
321
Category
Article
ISSN
0300-8177

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The alpha 1 subunit of the L-type Ca2+ channel plays a dual role in skeletal muscle. It is essential both for L-type Ca2+ channel activity and for the functioning of the voltage-sensor structure that is situated in the triads as a key element for excitation-contraction coupling. This paper shows, wi