Inhibitory effects of large Ca2+-activated K+-channel blockers on β-adrenergic- and NO-donor-mediated relaxations of human and guinea-pig airway smooth muscles

Relaxant Effects of the Potassium Channe

Relaxant Effects of the Potassium Channel Activators BRL 38227 and Pinacidil on Guinea-pig and Human Airway Smooth Muscle, and Blockade of Their Effects by Glibenclamide and BRL 31660

✍ D.R. Buckle; J.R.S. Arch; N.E. Bowring; K.A. Foster; J.F. Taylor; S.G. Taylor; D 📂 Article 📅 1993 🏛 Elsevier 🌐 English ⚖ 525 KB

SUMMARY: The airways relaxant effects and mechanism of action of the potassium channel activators BRL 38227 and pinacidil have been compared in guinea-pig and human airways. BRL 38227 was a potent relaxant in guinea-pig isolated trachealis ( \(\mathrm{IC}_{50}=4.9 \times 10^{-7} \mathrm{M}\) against