Prevalence of the 281 (Gly→Glu) mutation in hepatoerythropoietic porphyria and porphyria cutanea tarda
✍ Scribed by Hubert de Verneuil; Joanna Hansen; Christiane Picat; Bernard Grandchamp; James Kushner; Andrew Roberts; George Elder; Yves Nordmann
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 277 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0340-6717
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📜 SIMILAR VOLUMES
Sporadic porphyria cutanea tarda (PCT) is caused by a reduced activity of uroporphyrinogen decarboxylase (URO-D) in the liver. Mild to moderate iron overload is common in PCT, as iron is one of the factors which trigger the clinical manifestations of the disease through the inactivation of URO-D. A
Previous studies from Spain, Italy, and France have demonstrated a high prevalence (71% to 91%) of antibodies against hepatitis C virus in patients with porphyria cutanea tarda (PCT). To determine the role of hepatitis C virus (HCV) in PCT in Germany, we have assessed the prevalence of antibodies ag