Prevalence of LMP1 deletion variant of Epstein-Barr virus in nasopharyngeal carcinoma and gastric tumors in Hong Kong
β Scribed by Siu-Tim Cheung; Kwok-Wai Lo; S. F. Leung; Wing-Yee Chan; Peter H. K. Choi; P. J. Johnson; Joseph C. K. Lee; Dolly P. Huang
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- French
- Weight
- 231 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0020-7136
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β¦ Synopsis
Prevalence of LMPl deletion variant of Epstein-Barr virus in nasopharyngeal carcinoma and gastric tumors in Hong Kong
Chang et al. (1995) have described a prevalent strain of Epstein-Burr virus (EBV) associated with T-cell lymphoma and nasopha yngeal carcinoma (NPC) in the Taiwanesepopu-
π SIMILAR VOLUMES
We reported previously that a characteristic Epstein-Barr virus latent membrane protein 1 (EBV-LMP1) gene was associated with nasopharyngeal carcinoma (NPC) in Hong Kong. It showed a 30 bp deletion at the carboxyl terminus with specific amino acid substitution Asp at codon 335 with reference to Gly
## Forty -six samples of oral squamous cell carcinoma (OSCC) were evaluated for the prevalence of Epstein-Barr virus (EBV) infection by the polymerase chain reaction (PCR), Southern blot hybridization, and in situ hybridization (ISH). EBV DNA was detected in 7 (15β’2 per cent) out of 46 samples by
## RESULTS. In specimens from 107 patients with NPC, EBV was detected by PCR in 2 Department of Pathology, the Johns Hopkins 97 cases (90.7%) and by EBER in situ hybridization in 105 cases (98.1%). In speci-
A specific variant of Epstein-Barr virus (EBV) with a 30-bp deletion in the C-terminal region of the LMP1 gene has been found in some EBV-associated malignancies. To better understand the tumorigenic role of this LMP1 variant, we used PCR and sequencing to examine the LMP1 gene in 38 EBVassociated c