✦ LIBER ✦

Prevalence of HPV infection in esophageal squamous cell carcinoma in Chinese patients and its relationship to the p53 gene mutation

✍ Scribed by De He; De-Kai Zhang; King-Yin Lam; Lily Ma; Hextan Yuen-Sheung Ngan; Stephanie Si Liu; Sai-Wah Tsao

Publisher: John Wiley and Sons
Year: 1997
Tongue: French
Weight: 204 KB
Volume: 72
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19970917)72:6<959::aid-ijc7>3.0.co;2-o

No coin nor oath required. For personal study only.

✦ Synopsis

Human papillomavirus (HPV), in particular types 16 and 18, is positively associated with anogenital cancers and may be an important etiologic factor in their pathogenesis. The goal of our study was to investigate the role of HPV infection in the pathogenesis of esophageal squamous cell carcinoma (ESCC) and its relationship with the p53 mutation. We have examined ESCC collected from Sichuan, China, for the presence of HPV infection and p53 mutation. The presence of HPV DNA was detected by PCR-Southern analysis while the p53 mutation was analyzed by PCR-SSCP. High-risk HPV (types 16 and 18) DNA was detected in 32 out of 152 cases of ESCC examined. In contrast, HPV DNA was not detected in normal esophageal tissues excised from the distant end (tumor free) of resected ESCC. Mutation of the p53 gene was detected in 22 out of 55 cases of ESCC. The distribution of the 22 p53 mutation was: 5 in exon 5, 1 in exon 6, 5 in exon 7, 10 in exon 8 and 1 in exon 10. The p53 mutation was detected at a significantly lower rate in ESCC with HPV infection. Our results support a role of HPV infection in the pathogenesis of ESCC from a high-incidence area. Int.

📜 SIMILAR VOLUMES

p53 mutations in relation to human papil

p53 mutations in relation to human papillomavirus type 16 infection in squamous cell carcinomas of the head and neck

✍ Andrea G.M. Scholes; Triantafillos Liloglou; Peter J.F. Snijders; C. Anthony Har 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 66 KB 👁 1 views

Prevalence and predictive value of p53 m

Prevalence and predictive value of p53 mutation in patients with oesophageal squamous cell carcinomas: A prospective clinico-pathological study and survival analysis of 70 patients

✍ King Y. Lam; Sai W. Tsao; Dekai Zhang; Simon Law; Dan He; Lily Ma; John Wong 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 220 KB 👁 1 views

The tissues from 70 Chinese patients with oesophageal squamous cell carcinoma were prospectively collected to study for the pattern of p53 mutations and its relationship with clinico-pathological features and prognosis using immunohistochemistry, polymerase chain reaction-single strand conformationa

Mutations of the p53 gene in oral squamo

Mutations of the p53 gene in oral squamous-cell carcinomas from sudanese dippers of nitrosamine-rich toombak and non-snuff-dippers from the Sudan and Scandinavia

✍ Salah O. Ibrahim; Endre N. Vasstrand; Anne C. Johannessen; Ali M. Idris; Bengt M 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 100 KB 👁 1 views

Using PCR-SSCP/DNA sequencing methods, we analyzed 14 oral squamous-cell carcinomas (OSCCs) and 8 premalignant oral lesions from different Sudanese patients for prevalence of mutations in exons 5 to 9 of the p53 gene in relation to toombak-dipping status. OSCCs (14 from Sudan, 28 from Scandinavia),