Prevalence of HBeAg, anti-HBe serological markers and HBV-DNA in asymptomatic carriers in Ethiopia

✍ Scribed by M. Rapicetta; K. Hailù; G. Morace; L. Bisanti; A. M. Rienzo; A. R. Ciccaglione; D. Bekura; P. Pasquini; G. B. Rossi

• Publisher: Springer
• Year: 1989
• Tongue: English
• Weight: 394 KB
• Volume: 5
• Category: Article
• ISSN: 0393-2990
• DOI: 10.1007/bf00140145

✦ Synopsis

Data on the distribution of HBV-DNA and other serological markers of hepatitis B virus infection in a population of asymptomatic carriers in Ethiopia are reported. As compared to data from other countries of similar or lower levels of endemicity, it has been found that HBV-DNA prevalence and its correlation with HBeAg/anti-HBe status is similar to that of northern Europe. HBV-DNA is present in 84% of HBe Ag-positive sera but in only 4% of anti-HBe-positive sera, where the lowest concentration of DNA (less than 5 pgr/20 microliters) was found. The trend of increasing prevalence of serological markers with age seems to indicate a considerable horizontal transmission still present in this age range (18-30). In keeping with data of other authors a 3% of HBV-DNA positivity in anti HBc only positive sera was found. No regional or ethnical differences of HBV-DNA positive sera across the country were observed. There is also no evidence of any correlation between HBV-DNA prevalence and HBsAg subtypes ad and ay.