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Prevalence of factor V Leiden in a population of patients with congenital heart disease

✍ Scribed by Biauw-Chi Ong; A. Andrew Zimmerman; David C. Zappulla; Ellis J. Neufeld; Frederick A. Burrows


Publisher
Springer-Verlag
Year
1998
Tongue
French
Weight
422 KB
Volume
45
Category
Article
ISSN
1496-8975

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Prevalence of factor V Leiden mutation i
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Resistance to activated protein C (APC) is the most common inherited risk factor for venous thrombosis. Most cases of APC resistance are caused by the point mutation nt 1691 G-A in factor V gene, referred to as factor V Leiden mutation. As initially shown in a Dutch population, this mutation has a c

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Resistance to activated protein C (APC) is the most common risk factor for venous thromboembolism, a major cause of morbidity and mortality with an incidence of about 1/1,000 per year. The Arg 506 to Gln mutation in exon 10 of the coagulation factor V gene (factor V-Leiden) has been found to be resp