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Prevalence of drug hydroxylator phenotypes in Belgium

✍ Scribed by V. Leclercq; J. P. Desager; Y. Nieuwenhuyze; C. Harvengt


Publisher
Springer
Year
1987
Tongue
English
Weight
116 KB
Volume
33
Category
Article
ISSN
0031-6970

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Hydroxylation at C-3' of doxorubicin (DOX) yields the uncharged congener hydroxyrubicin, which circumvents P-glycoprotein-mediated drug resistance without loss of topoisomerase II inhibitory activity. Hydroxyrubicin-resistant cells exhibit a phenotype that is uniquely different from DOX resistance b