Prevalence and Prognostic Significance of Poor Differentiation and Tall Cell Variant in Papillary Carcinoma in Japan
β Scribed by Yasuhiro Ito; Mitsuyoshi Hirokawa; Mitsuhiro Fukushima; Hiroyuki Inoue; Tomonori Yabuta; Takashi Uruno; Minoru Kihara; Takuya Higashiyama; Yuuki Takamura; Akihiro Miya; Kaoru Kobayashi; Fumio Matsuzuka; Akira Miyauchi
- Book ID
- 105980077
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 365 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0364-2313
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Cytologic reports of the aggressive tall-cell and diffuse sclerosing variants of papillary carcinoma have emphasized features such as tall and large cells, increased nuclear size, nuclear pleomorphism, intranuclear pseudoinclusions, three-dimensional tissue fragments, squamous-like cells, and dense
## Abstract ## BACKGROUND Tall cell variant papillary carcinoma of the thyroid demonstrates unusually aggressive clinical behavior compared with the usual form of papillary thyroid carcinoma. The protoβoncogene cβ__met__ encodes a tyrosine kinase receptor known to influence cell invasion. This cur