Pretumor Progression: Clonal Evolution of Human Stem Cell Populations
✍ Scribed by Peter Calabrese; Simon Tavaré; Darryl Shibata
- Book ID
- 117021546
- Publisher
- American Society for Investigative Pathology
- Year
- 2004
- Tongue
- English
- Weight
- 542 KB
- Volume
- 164
- Category
- Article
- ISSN
- 0002-9440
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Mesenchymal stem cells (MSCs) have attracted immense research interest in the field of regenerative medicine due to their ability to be cultured for successive passages and multi‐lineage differentiation. The molecular mechanisms governing MSC self‐renewal and differentiation remain larg
In general, it is presumed that colonic epithelial stem cells are the principal cell type at risk of incurring the series of somatic mutations leading to carcinoma, since all other epithelial cell types are short-lived. Mutant stem cell clonal expansion increases the risk for subsequent mutations an