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Presynaptic inhibitory action of the group II metabotropic glutamate receptor agonists, LY354740 and DCG-IV

โœ Scribed by John Kilbride; LingQian Huang; Michael J. Rowan; Roger Anwyl


Book ID
114016531
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
608 KB
Volume
356
Category
Article
ISSN
0014-2999

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Stereocontrolled synthesis of a potent a
โœ Yasufumi Ohfune; Takashi Demura; Seiji Iwama; Hiromi Matsuda; Kosuke Namba; Keik ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 258 KB

Efficient synthesis of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740: 1) and its structurally related analogs (-)-2 and (-)-3 has been accomplished starting with (1S,2R)-1-amino-2-hydroxycyclopentane-or cyclohexanecarboxylic acid (4 or 17 ) via an intramolecular cyclopropanation of