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Presenilins: Multifunctional Proteins Involved in Alzheimer's Disease Pathology

✍ Scribed by Frederic Checler


Book ID
111743259
Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
180 KB
Volume
48
Category
Article
ISSN
1521-6543

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Presenilin mutations in Alzheimer's dise
✍ Marc Cruts; Christine Van Broeckhoven πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 212 KB πŸ‘ 2 views

The presenilins (PS-1 and PS-2) are 2 members of a novel family of genes encoding integral membrane proteins recently implicated in Alzheimer's disease (AD) pathology. To date, 43 mutations have been identified in PS-1 and 2 in PS-2 that lead to familial presenile AD (onset before age 65 years). The