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Presenilin-1 expression in Pick’s disease

✍ Scribed by P. Giannakopoulos; Enikò Kövari; Luc Buée; Junichi Shioi; Patrick R. Hof; Nikolaos K. Robakis; Constantin Bouras

Publisher
Springer-Verlag
Year
1999
Tongue
English
Weight
219 KB
Volume
98
Category
Article
ISSN
0001-6322

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✍ Marc Cruts; Christine Van Broeckhoven 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 212 KB 👁 2 views

The presenilins (PS-1 and PS-2) are 2 members of a novel family of genes encoding integral membrane proteins recently implicated in Alzheimer's disease (AD) pathology. To date, 43 mutations have been identified in PS-1 and 2 in PS-2 that lead to familial presenile AD (onset before age 65 years). The