Cytoskeletal alterations differentiate presenilin-1 and sporadic Alzheimer’s disease
✍ Scribed by Adele Woodhouse; Claire E. Shepherd; Anna Sokolova; Victoria L. Carroll; Anna E. King; Glenda M. Halliday; Tracey C. Dickson; James C. Vickers
- Publisher
- Springer-Verlag
- Year
- 2008
- Tongue
- English
- Weight
- 728 KB
- Volume
- 117
- Category
- Article
- ISSN
- 0001-6322
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Recent reports have shown an association between an intronic polymorphism of the presenilin-1 (PSEN1) gene and late-onset (age at onset > 65) familial and sporadic (no family history) Alzheimer disease (AD). The reported association was independent of the effect of the only previously identified gen
## Background: Early-onset familial alzheimer's disease (eofad) is linked to mutations in three autosomal dominant genes: ps1, ps2 and app. the clinical presentation and age of onset of mutations is variable. ## Objectives: The aim of this report is to describe a novel ps1 mutation believed to be