Presence of novel N-CAM glycoforms in the rat olfactory system

✍ Scribed by Dowsing, B. ;Puche, A. ;Hearn, C. ;Key, B.

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 486 KB
• Volume: 32
• Category: Article
• ISSN: 0022-3034
• DOI: 10.1002/(sici)1097-4695(19970620)32:7<659::aid-neu2>3.0.co;2-3

✦ Synopsis

The functional activity of the neural gether; and OMP alone. The NOC-3-and NOC-4cell adhesion molecule N-CAM can be modulated by expressing neurons were widely dispersed in the olposttranslational modifications such as glycosylation. factory neuroepithelium lining the nasal cavity. The For instance, the long polysialic acid side chains of axons of NOC-4 expressing neurons innervated all glo-N-CAM alter the adhesion properties of the protein meruli in the olfactory bulb, whereas the NOC-3 exbackbone. In the present study, we identified two pressing axons terminated in a discrete subset of glonovel carbohydrates present on N-CAM, NOC-3 and meruli scattered throughout the whole olfactory bulb. NOC-4. Both carbohydrates were detected on N-CAM We propose that both NOC-3 and NOC-4 are part of glycoforms expressed by subpopulations of primary a chemical code of olfactory neurons which is used in sensory olfactory neurons in the rat olfactory system. establishing the topography of connections between Based on the expression of NOC-3 and NOC-4 and the the olfactory neuroepithelium and the olfactory bulb. olfactory marker protein (OMP), four independent