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Presence of Merkel cells in sun-exposed and not sun-exposed skin: a quantitative study

✍ Scribed by I. Moll; U. Bladt; E. G. Jung

Book ID
104745531
Publisher
Springer-Verlag
Year
1990
Tongue
English
Weight
703 KB
Volume
282
Category
Article
ISSN
0340-3696

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✦ Synopsis

Merkel cells (MCs), the neuroendocrine cells of the skin cannot be identified with certainty using conventional light microscopic staining methods. Using immunoperoxidase microscopy with antibodies specific for cytokeratin 18, which has been established as a marker protein of MCs, we have evaluated the numbers of MCs per mm 2 skin in normal and sun-damaged upper arm skin. The sunexposed skin contained twice as many MCs as the not sun exposed skin. Further quantification of MC density at various body sites (trunk, leg) showed a rather variable but often unexpectedly high MC density. The possible role of MC in development of actinic elastosis is discussed.

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