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UV-specific p53 and PTCH mutations in sporadic basal cell carcinoma of sun-exposed skin

✍ Scribed by Désirée Ratner; Monica Peacocke; Hong Zhang; Xiao Li Ping a; Hui C. Tsou

Book ID
117844887
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
383 KB
Volume
44
Category
Article
ISSN
1097-6787

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Mutations in the p53 gene in 32 basal-cell carcinomas (BCC) developed in Japanese patients were identified by the polymerase chain reaction and single-strand-conformation polymorphism analysis, followed by sequencing the DNA. Among 16 BCC developed in continuously sun-exposed areas, 6 tumors showed