Presence of IgM antibodies to Trypanosoma cruzi urinary antigen in sera from patients with acute Chagas' disease
β Scribed by R.S. Corral; J.M. Altcheh; H.L. Freilij
- Book ID
- 118531897
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 761 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0020-7519
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This report describes differences in humoral immune response of acute and chronic phases of human Chagas disease. The reactivities of IgG, IgM, and IgA anti-Trypanosoma cruzi antibodies in serum samples from both groups of patients were compared by enzyme-linked immunosorbent assay (ELISA) employing
Protective, lytic antibodies are believed to be correlated with active Pypanosoma cruzi infection. In patients with chronic infection, antibodies lysing trypomastigote forms recognize chiefly a-galactosyl structures at the parasite surface. The target molecules on cell-derived trypomastigotes that r