Glycoconjugates of Trypanosoma cruzi: A 74 kD antigen of trypomastigotes specifically reacts with lytic anti-α-galactosyl antibodies from patients with chronic Chagas disease
✍ Scribed by Igor C. Almeida; Greice M. Krautz; Antoniana U. Krettli; Dr. Luiz R. Travassos
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 1016 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0887-8013
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✦ Synopsis
Protective, lytic antibodies are believed to be correlated with active Pypanosoma cruzi infection. In patients with chronic infection, antibodies lysing trypomastigote forms recognize chiefly a-galactosyl structures at the parasite surface. The target molecules on cell-derived trypomastigotes that react with anti-a-galactosyl antibodies (anti-Gal) from patients with chronic Chagas disease were investigated, Glycoconjugates were isolated from trypomastigotes and shown to absorb purified Chagasic (Ch) anti-Gal effectively as well as lytic antibodies from Ch sera. Active fractions were F2 (74 kD and 95.6 kD)