Using comparative genomic hybridization (CGH), we have identified and mapped regions of DNA amplification in primary and metastatic osteosarcoma. Samples were obtained from four patients and ten independent xenogmfts. Sixty-four percent of the tumors showed increased DNA-sequence copy numbers, affec
Presence of double minutes and monosomy 17p in xenografted human osteosarcomas
✍ Scribed by Concha López-Ginés; Carmen Carda-Batalla; Lola López-Terrada; Antonio Llombart-Bosch
- Book ID
- 113253795
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 795 KB
- Volume
- 90
- Category
- Article
- ISSN
- 0165-4608
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## Abstract Gene amplification plays a pivotal role in human malignancy. Highly amplified genes frequently localize to extrachromosomal double minutes (dmin), which usually segregate to daughter cells in association with mitotic chromosomes. We and others had shown that treatment with low‐dose hydr