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Comparative genomic hybridization analysis of human sarcomas: II. Identification of novel amplicons at 6p and 17p in osteosarcomas

✍ Scribed by Anne Forus; Daniël Olde Weghuis; Dominique Smeets; Øystein Fodstad; Ola Myklebost; Ad Geurts van Kessel

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
521 KB
Volume
14
Category
Article
ISSN
1045-2257

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✦ Synopsis

Using comparative genomic hybridization (CGH), we have identified and mapped regions of DNA amplification in primary and metastatic osteosarcoma. Samples were obtained from four patients and ten independent xenogmfts. Sixty-four percent of the tumors showed increased DNA-sequence copy numbers, affecting 23 different chromosomal sites. Most of these regions were not previously associated with the development andlor progression of these tumors. Amplicons originating from I q2 I-q23,6p, 8q23qter, and 17plI-pI2 were observed most frequently. The 6p and 17pl I-pI2 amplicons seem to be specific for osteosarcomas, indicating that these regions may harbor genes relevant for the development of these tumors. Genes Chrornosom Cancer /4:15-21 (1995).

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