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Presence of Dominant-Negative p53 Mutation Is a Risk of Early Recurrence in Oral Squamous Cell Carcinoma

✍ Scribed by Haruhiko Kashiwazaki

Book ID
113737803
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
46 KB
Volume
65
Category
Article
ISSN
1531-5053

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Detection of p53 gene mutations in oral
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Mutations in the p53 gene have been reported in head and neck carcinomas. We determined the p53 mutation profile in 55 oral squamous cell carcinomas (OSCCs) from a black African population sample. DNA from all the patients were investigated using PCR amplification of the p53 gene (exons 5-9), follow