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Presence of a volatile substance mistaken for diethylene glycole in plasma in a case of valproic acid overdose

✍ Scribed by D.A. Colantonio; W. Walsh; M. Thompson; Z. Verjee


Book ID
118431900
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
73 KB
Volume
45
Category
Article
ISSN
0009-9120

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A thin-layer chromatographic (TLC) method is described for the assay of the anti-epileptic drug, valproic acid, in plasma. The use of high-performance (HPTLC) plates gave sensitive detection limits (4.87 micrograms ml-1) for derivatives of valproic acid and the reproducibility on the same or differe