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Thin-layer chromatography and densitometry in drug assay: Comparison of methods for monitoring valproic acid in plasma

✍ Scribed by P. Corti; A. Cenni; G. Corbini; E. Dreassi; C. Murratzu; A.M. Caricchia

Publisher: Elsevier Science
Year: 1990
Tongue: English
Weight: 455 KB
Volume: 8
Category: Article
ISSN: 0731-7085
DOI: 10.1016/0731-7085(90)80071-v

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✦ Synopsis

A thin-layer chromatographic (TLC) method is described for the assay of the anti-epileptic drug, valproic acid, in plasma. The use of high-performance (HPTLC) plates gave sensitive detection limits (4.87 micrograms ml-1) for derivatives of valproic acid and the reproducibility on the same or different plates was good. Comparison with high-performance liquid chromatography showed a similar performance of plate and column.

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