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Preparative steps necessary for the accurate measurement of malondialdehyde by high-performance liquid chromatography

✍ Scribed by Guy Lepage; Gabriel Munoz; Josée Champagne; Claude C. Roy

Book ID
107718966
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
767 KB
Volume
197
Category
Article
ISSN
0003-2697

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Malondialdehyde, which is generated by lipid peroxidation, can form DNA-protein and/or interstrand DNA crosslinks. The biological consequences of inaccurate repair of these crosslinks may be severe. The expected levels of crosslinking of DNA in vivo are low, and an extremely sensitive method must be