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Preparative resolution of some 5,5-hydantoin derivatives via formation of diastereoisomeric salts

✍ Scribed by Gérard Coquerel; Marie-Noëlle Petit; Roger Bouaziz; Dominique Depernet

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
266 KB
Volume
4
Category
Article
ISSN
0899-0042

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✦ Synopsis

Several preparative resolutions of 5,5-disubstituted hydantoins have been achieved via fractional crystallization of diastereoisomeric salts. The process can be extended by making use of the difference between the variation of solubilities of the hydantoins and their salts with a-methylbenzylamine as a function of the alkalinity of the medium. Optimization for each resolution procedure involves a refinement of the excess amount of base needed.

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