✦ LIBER ✦
Annelation of 5 or 6 membered heterocycles to uracil derivatives via phosgeniminium salt(1) condensation
✍ Scribed by B. Kokel; C. Lespagnol; H. G. Viehe
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2010
- Weight
- 244 KB
- Volume
- 89
- Category
- Article
- ISSN
- 0037-9646
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✦ Synopsis
Abstract
PI salts condense with 1, 3‐dimethyl barbituric acid and 1, 3‐dimethyl‐4 ‐amino uracil to give new amide chlorides 4 and 5. These synthons lead to new aminated isoxazolo‐, or pyrimido‐ and pyrido‐pyrimidines 12, 16 & 18 on cyclisation with hydroxylamine, cyanamide and malononitrile, respectively.