A method combining flow sorting and molecular cytogenetic techniques for the identification of unknown marker chrornosomes is described. In this study, the bladder tumor cell line 182 was used, which was known t o carry a marker chromosome of the size of chromosome 7 in every cell. From the cytogene
✦ LIBER ✦
Preparative dual-beam sorting of the human Y chromosome and in situ hybridization of cloned DNA probes
✍ Scribed by C. Cremer; G. Rappold; J. W. Gray; C. R. Müller; H.-H. Ropers
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 833 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0196-4763
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Paclitaxel is a recent chemotherapeutic agent that inhibits tubulin depolymerization in tumoral cells. Despite its increasing use against various human cancers, the genotoxicity of paclitaxel has never been studied on normal human cells. The in vitro genotoxic effects of the drug were evaluated with