Preparations of angularly trifluoromethylated compounds
β Scribed by Yuji Hanzawa; Hisanaka Ito; Kohara Noriko; Sasaki Hirofumi; Fukuda Hiroshi; Morikawa Tsutomu; Takeo Taguchi; Yoichi Iitaka
- Book ID
- 104216259
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 275 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
Angularly trijluoromelhylated crs-bicyclrc compounds were effectively produced by rntramolecular radical ondMchae1 addltron reactions As a ryprcai target molecule, 19,19.19-rrrfluorosreroid was prepared umg (~1 angularly tnfluoromethylated brcychc compound
π SIMILAR VOLUMES
IReceived in Japan 4 August 1969; received in UK for publication 4 September 1969) V./e wish to rewort on. a new method to in.troduce Cl?3 group into the desired Wosition of the aromatic rinq.
The direct reaction of 1 with TMS-CN in the presence of ZnI2 readily proceeded. The cyanohydrin 2. was hydrized to trifluorolactic acid, and converted to the I-menthyl ester3 and j\_ was separated to each diastemomers ((.5)-(-)-z and @Q-(+)-a). On the other hand, stereoselective cyanohydrin reaction