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Preparation, purification, and analysis of alkylated cyclodextrins

✍ Scribed by Schomburg, Gerhard ;Deege, Alfred ;Hinrichs, Heike ;Hübinger, Eduard ;Husmann, Heribert

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
473 KB
Volume
15
Category
Article
ISSN
0935-6304

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✦ Synopsis

Abstract

Methods of alkylation of α‐, β‐ and γ‐cyclodextrins have been optimized with regard to the parameters of reaction, degree of alkylation and yields. The analysis of the reaction mixtures and of the isolated single species has been performed by high temperature GC and HPLC. The phase systems of the preferably applied HPLC have been carefully adjusted by variation of both the stationary and mobile phases to the very different hydrophobicities of the various alkylated CD species which have been synthesized. Several partially or fully alkylated CD species were isolated from preparative scale HPLC separations in high purity.

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